Clinical Study
Myelofibrosis-Associated Lymphoproliferative Disease: Retrospective Study of 16 Cases and Literature Review
Table 2
Reported cases of myelofibrosis and lymphoproliferative disease.
| | Sex/Age | Histology | MF degree | B-symptoms | Lymph nodes | SMG | HMG | LDH | Treatment | Response | FU (mo) | Outcome |
| | Takai and Sanada [14] | F/65 | T-NHL | marked | + | + | − | − | increased | CHOP | CR | 9 | A | | Kimura et al. [15] | H/55 | B-CLL | moderate to severe | na | + | + | + | na | COP, CLB | PR | 11 | A | | Pulsoni et al. [13] | F/58 | PCM | extensive | + | − | + | + | na | MP, VMCP-VBAP | PR, relapse | 44 | D | | Orth [12] | F/55 | T-NHL | na | na | + | + | + | na | Prednisone, Vincristine | PR | 4 | A | | Meckenstock et al. [10] | H/36 | B-NHL | diffuse | + | − | + | + | increased | corticosteroid | — | 3 | D | | Weirich et al. [16] | H/42 | T-NHL | marked, diffuse | + | − | + | + | na | CHOP, splenectomy | PR | 2 | A | | Stevenson et al. [8] | F/60 | PCM | diffuse | + | − | + | + | na | VAD, melphalan + ASCT | CR | 24 | A | | Kasahara et al. [11] | F/68 | B-NHL | marked | + | − | − | − | na | CHOP | PR | na | D | | Abe et al. [19] | F/19 | T-NHL | diffuse | na | + | + | + | increased | CHOP | CR | 24 | A | | Uehara et al. [9] | H/69 | T-NHL | diffuse | − | + | + | na | increased | na | PR, relapse | 30 | D | | Rao et al. [7] | F/46 | T-NHL | marked | + | + | + | + | increased | Splenectomy CHOP and ICE | CR after ICE | 11 | A | | Matsunaga et al. [6] | F/73 | B-NHL | 4+ | + | − | + | | increased | Splenectomy, fludarabine, cyclophosph | CR | 12 | D | | Okabe et al. [4] | H/68 | T-NHL | diffuse | na | − | + | − | N | Cyclophos, oncovin, prednisone | refractory | 9 | D | | Hatta et al. [20] | H/67 | B-NHL | NA | − | + | − | − | increased | na | refractory | 14 | D | | Hagihara et al. [5] | H/68 | B-NHL | NA | + | − | + | + | increased | CHOP | CR | na | A |
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A: alive; CR: complete remission; CLB: chlorambucil; CLL: chronic lymphocytic lymphoma; D: death; HMG: hepatomegaly; ICE: ifosfamide cytarabine etoposide; NHL: non-hodgkin lymphoma; PCM: plasma cell myeloma; na: not available; PR: partial remission; Prog: progressive; SMG: splenomegaly; : present; : absent.
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