Advances in Hematology / 2009 / Article / Fig 5

Research Article

Functional Characterization of the Canine Heme-Regulated eIF2 Kinase: Regulation of Protein Synthesis

Figure 5

Inhibition of HRI kinase activity by quercetin. The kinase activity of the purified human, mouse and canine HRI proteins was determined using an in-vitro kinase assay in the presence of various concentrations of quercetin from 0.01  M to 100  M, shown in log M units. The data are expressed as a percent of activity compared to a vehicle control at 100% at the end of the two hour reaction. All experiments were performed in duplicate or triplicate with the mean ± SEM represented.
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