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Advances in Hematology
Volume 2010, Article ID 136252, 4 pages
http://dx.doi.org/10.1155/2010/136252
Case Report

Successful Pregnancy and Delivery in a Patient with Chronic Myeloid Leukemia while on Dasatinib Therapy

1Department of Hematology, Faculty of Medicine, University of São Paulo, SP 05403-000, Brazil
2Fundação Pro-Sangue, Hemocentro de São Paulo, SP 05403-000, Brazil

Received 11 November 2009; Accepted 9 January 2010

Academic Editor: Stefan Faderl

Copyright © 2010 Monika Conchon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Here we report the case of an 18-year-old woman with chronic myeloid leukemia (CML) who became pregnant while undergoing treatment with dasatinib. Before pregnancy, she received imatinib mesylate therapy but could not tolerate the treatment. The regimen was then changed to dasatinib at a dose of 70 mg b.i.d. While she was in hematological remission and on dasatinib therapy, she became pregnant. The unplanned pregnancy was identified after the patient had experienced four weeks of amenorrhea. Because the patient elected to continue the pregnancy to term, dasatinib was stopped immediately. Meanwhile, CML hematological relapse occurred and then she was treated with interferon- 𝛼 (IFN- 𝛼 ) (9 million IU/day) throughout the pregnancy without a complete hematological response. She successfully gave birth to a male baby at 33 weeks by cesarean section delivery with no sequelae or malformations. Although this experience is limited to a single patient, it provides a useful contribution for counselling patients inadvertently exposed to dasatinib during pregnancy.