Review Article
Impact of Autologous and Allogeneic Stem Cell Transplantation in Peripheral T-Cell Lymphomas
Table 3
Studies on High-Dose Therapy and Allogeneic Stem Cell Transplantation in PTCL.
| (a) Retrospective data |
| | Author | Year | | Age | Histologies | IPI | Previous autoSCT | Regimen (MA versus RIC) | Status at Tx | DFS/EFS/ PFS | OS | TRM/NRM | Followup (months) | GVHD |
| | Feyler et al. [40] | 2007 | 18 | 28 | PTCLu 50%
T-cell leuk. 28%
ALCL 17%
CTCL 6% | 0/1 33%
≥2 66% | 11% | 100% MA | No data | 33% (3 y) | 39% (3 y) | | 57 | Acute GVHD °3/4: 28%
Ext. chronic GVHD: 6% |
| | Murashige et al. [51] | 2005 | 28 | 38 | NK/T 79%
Blastic NK 11%
NK-leukemia 11% | No data | 32% | 82% versus 18% | CR 57% | 34% (2 y) | 40% (2 y) | 29% | 34 | Acute GVHD °3/4: 29%
Ext. chronic GVHD: 11% |
| | Hamadani et al. [52] | 2008 | 14 | 43 | PTCLu 36%
AITL 28%
ALCL 14%
NK/T 14%
Other 7% | aaIPI
0/1 57%
2/3 42% | 14% | 57% versus 43% | CR 21%
PR 35% | 31% (3 y) | 35% (3 y) | | 34 | Acute GVHD °3/4: 21%
Chronic GVHD: 50% |
| | Le Gouill et al. [53] | 2008 | 77 | 36 | PTCLu 35%
ALCL 35%
AITL 14%
Other 16% | 0/1 61%
≥2 32%
Unknown 6% | 25% | 74% versus 26% | CR 40%
PR 30% | 53% (5 y) | 57% (5 y) | | 43 | Acute GVHD °3/4: 21% |
| | Kyriakou et al. [54] | 2009 | 45 | 48 | AITL 100% | No data | 33% | 56% versus 45% | CR 27%
PR 22% | 53% (3 y) | 64% (3 y) | | 29 | Acute GVHD °3/4: 11%
Ext. chronic GVHD: 24% |
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| (b) Prospective data |
| | Author | Year | | Age | Histologies | IPI | Previous autoSCT | Regimen (MA versus RIC) | Status at Tx | DFS/EFS/ PFS | OS | TRM/NRM | Followup (months) | GVHD |
| | Corradini et al. [55] | 2004 | 17 | 41 | PTCLu 53%
ALCL 24%
AITL 24% | aaIPI
0/1 24%
2/3 76% | 47% | 100% RIC | CR 12%
PR 71% | 64% (3 y) | 81% (3 y) | 6% | 28 | Acute GVHD 12%
Ext. chronic GVHD: 6% |
| | Wulf et al. [56] | 2005 | 10 | 45 | PTCLu 40%
ALCL 30%
AITL 20%
T-PLL 10% | No data | 20% | 100% RIC | CR 10%
PR 50% | 60% (7 m) | 70% (7 m) | 30% | 7 | Acute GVHD 10%
Ext. chronic GVHD: 50% |
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at day 100.
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