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Advances in Hematology
Volume 2010, Article ID 624040, 8 pages
Review Article

Peripheral T-Cell Lymphoma: Review and Updates of Current Management Strategies

1Department of Medical Oncology, The National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610
2Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608

Received 1 September 2010; Accepted 14 November 2010

Academic Editor: Jorge Enrique Romaguera

Copyright © 2010 Tiffany Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The classification of T-cell and natural-killer- (NK-) cell lymphomas has been updated in the 4th edition of the World Health Organization (WHO) classification of tumors of the haematopoietic and lymphoid tissue published in 2008. Based on recent epidemiological studies, NK-cell lymphomas occur almost exclusively in Asia and South America, although T-cell lymphomas appear to occur in the East as commonly as in the West. Due to the low prevalence of this disease, diagnosis and optimal treatment of patients have not been studied prospectively in large randomized trials. Nevertheless, there has been development in the understanding of T-cell lymphomas and how they should be managed; FDG-PET emerges as an increasingly important tool in diagnosis, gene-expression signatures may aid with prognostication in the future, and novel therapies are currently being studied to improve outcomes in T-cell lymphomas. More work, however, needs to be done, and international collaboration will be pertinent to deriving meaningful results from future clinical studies.