Patients are middle-aged and elderly and most present with generalised lymphadenopathy, hepatosplenomegaly. Laboratory findings include circulating immune complexes, cold agglutinins, and haemolytic anaemia
CD4+ or Mixed CD4/8 CXCL13+, PD1+Majority BCL6+Half are CD10+ Hyperplasia of follicular dendritic cellsEBV+ Bcell
ALK-positive ALCL
Male predominance () and occurs in the first three decades of life. Most patients present with advanced-stage disease, peripheral and/or abdominal lymphadenopathy. They often have B symptoms especially fever
CD 30+ALK translocation is present Majority EMA+ Majority CD2+, CD5+, CD4+, TIA1+, granzyme B+ Majority CD3−, CD8−
ALK-negative ALCL
Compared to ALK+ ALCL, patients are older (40–65 year-old) and the clinical course is more aggressive. Similar to ALK+ ALCL, patients present with advanced disease, peripheral and/or abdominal lymphadenopathy, and B symptoms
CD30+ (strong and homogenous staining) Majority CD3+, CD4+, CD 43+ Minority EMA+PAX5−EBV markers EBER and LMP1 negative