Review Article
Targeting the Hepcidin-Ferroportin Axis in the Diagnosis and Treatment of Anemias
Table 1
Diagnostic and therapeutic potenital of hepcidin in different forms of anemia.
| Condition | Expected hepcidin levels | Other iron parameters | Hepcidin therapy |
| Iron deficiency anemia | Low | Low Tsat and ferritin | | Iron-refractory iron deficiency anemia | High | Low Tsat and ferritin | Antagonist | Iron-loading anemias | Low (unless transfused) | High Tsat and ferritin | Agonist | Anemia of inflammation | High | Low Tsat, normal-to-elevated ferritin | Antagonist | Mixed anemia (AI/IDA) | Normal | Low Tsat, low-to-normal ferritin | Antagonist | Chronic kidney disease | High | Variable | Antagonist | Erythropoietin resistance | High | Variable | Antagonist |
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Tsat transferrin saturation.
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