Echocardiographic Assessment of Left Ventricular Function in Type 1 Gaucher's Disease

Table 1

Echocardiographic parameters in patients and controls.

	Patients; 𝑛=15	Control subjects; 𝑛=18	𝑃 value
LV EF (%)	70.7±7.51	64.2±3.42	NS
𝐸 (cm/s)	88±17	91±19	NS
𝐴 (cm/s)	66±13	65±16	NS
𝐸/𝐴	1.36±0.35	1.46±0.44	NS
𝑆 (m/s)	0.59±0.09	0.59±0.14	NS
𝐷 (m/s)	0.56±0.11	0.63±0.14	NS
𝑆/𝐷	1.07±0.27	0.96±0.25	NS
𝐴 dur (ms)	125±19	139±26	NS
𝑎 dur (ms)	96±19	101±22	NS
𝐴/𝑎	1.34±0.27	1.44±0.32	NS
𝑆𝑚 (cm/s)	8.2±1.2	8.5±0.9	NS
𝐸𝑚 (cm/s)	11.2±4.1	13.3±2.8	0.095^∗
𝐴𝑚 (cm/s)	9.8±2.0	9.4±1.9	NS
𝐸/𝐸𝑚	8.8±3.3	7.3±1.8	0.097^∗
NT-proBNP (ng/L)	72±63	50±34	NS

Echocardiographic parameters: LV EF = left ventricular ejection fraction 𝐸 = flow velocity during early diastolic filling, 𝐴 = flow velocity during atrial contraction, late diastolic filling, 𝐸/𝐴 = 𝐸 wave/𝐴 wave ratio, 𝐴 dur = duration of mitral 𝐴-wave, 𝑎 dur = duration of retrograde a-wave in pulmonary venous flow, 𝐴/𝑎 = ratio between the duration of mitral 𝐴-wave and duration of 𝑎-wave in pulmonary venous flow, 𝑆/𝐷 = ratio between systolic and diastolic pulmonary venous flow, 𝑆_𝑚 = mitral annulus systolic tissue velocity, 𝐸_𝑚 = early mitral annulus diastolic tissue velocity, 𝐸/𝐸_𝑚 = ratio in early mitral diastolic flow and early mitral annulus diastolic tissue velocity, NT-proBNP = amino terminal pro brain natriuretic peptide, NS-statistically nonsignificant, and ∗statistically borderline values.