Photodynamic Therapy with the Silicon Phthalocyanine Pc 4 Induces Apoptosis in Mycosis Fungoides and Sezary Syndrome

Figure 1

Pc 4-PDT dose response for the induction of apoptosis in CD4⁺CD7⁻ malignant lymphocytes, CD4⁺CD7⁺ normal lymphocytes, and CD11b⁺ monocytes of patients with Sezary syndrome. Peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll-histopaque centrifugation and then treated with Pc 4 at 0–100 nM followed by photoirradiation (200 mJ/cm²).