Figure 2: Different approaches to target IE in β-thalassemia. The administration of hepcidin would allow to decrease the iron overload in organs such the liver and heart and to redistribute the iron to hematopoietic organs, allowing a more efficient erythropoiesis and therefore a decrease in splenomegaly. The administration of Jak2 inhibitors would induce a decrease in the inefficient erythropoietic rate, therefore decreasing spleen size. The reduced erythropoiesis would have as indirect effect the increase in serum hepcidin, that in turn would decrease the iron absorption from the gut and the amelioration of iron overload.