Hodgkin's Lymphomas: A Tumor Recognized by Its Microenvironment

Figure 2

The HRS cell and its cellular microenvironment. Significant interactions with impact in patients outcome are depicted. Increased Galectin1 and IL-10 secreted by HRS (Hodgkin and Reed-Sternberg) cells lead to decreased TCL (T cytotoxic) and Th1 responses, together with a Treg increase which, in turn, suppresses both Th2 and PD1+ T cell activity [46–51]. PD1+CD4+ T cell activity is additionally suppressed by direct interations trough PD1-PD1L immunological synapse (T cell exhaustion) [52]. This leads to a decreased IFN𝛾 production. Additionally, increased TAM (Tumor Associated Macrophages) contribute to T cell deletion trough STAT1 signaling pathway [53, 54].