Role of Factor Xa Inhibitors in Cancer-Associated Thrombosis: Any New Data?

Table 3

Multivariate analysis for major bleeding and bleeding risk index classification [60, 61].

(a)

Risk factors	Odds ratio (95% CI)	𝑃 value	Points
Recent major bleed	2.7 (1.6–4.6)	< 0.001	2.0
Serum creatinine (Scr) > 1.2 mg/dL	2.1 (1.7–2.8)	< 0.001	1.5
Anemia	2.1 (1.7–2.7)	< 0.001	1.5
Cancer	1.7 (1.4–2.2)	< 0.001	1.0
Clinically overt pulmonary embolism	1.7 (1.4–2.2)	< 0.001	1.0
Age > 75 years	1.7 (1.3–2.1)	< 0.001	1.0

0 points = low risk.
0.1% (95% CI: 0.0–0.2).
1–4 points = intermediate risk.
2.8% (95% CI: 2.4–3.3).
>4 points= high risk.
7.3% (95% CI: 4.0–9.1).

(b)

Risk factors	Odds ratio (95% CI)	𝑃 value	Points
Age > 75 years	2.16 (1.49–3.16)	< 0.001	1.0
Recent major bleed	2.64 (1.44–4.83)	0.002	1.5
Immobility ≥ 4 days	1.99 (1.40–2.83)	< 0.001	1.0
Metastatic cancer	3.80 (2.56–5.64)	< 0.001	2.0
Anemia	1.54 (1.07–2.22)	0.021	1.0
Platelet count < 100.000/mm^3	2.23 (1.16–4.29)	0.016	1.0
Elevated prothrombin time (PT)	2.09 (1.34–3.26)	0.001	1.0
Creatinine clearance (CrCl) < 30 mL/min	2.27 (1.49–3.44)	< 0.001	1.0
Distal deep vein thrombosis	0.39 (0.16–0.95)	0.038	−1.0

Score < 1.5 = low risk 0.16%.
LR = 0.29 (95% CI: 0.20–0.41).
Score 1.5–4 = intermediate risk 1.06%.
LR = 1.92 (95% CI: 1.69–2.17).
Score > 4 = high risk 4.24%.
LR = 7.95 (95% CI: 5.42–11.6).