|
| Authors, journal, and publication year | . patients | Type of samples | Measured criteria | Prognostic value |
|
| Aguayo et al. Blood, 2000 [14] | A : 28 | BM [20] and Plasma [23] (diagnosis) | MVD and plasmatic levels of VEGF and bFGF | Not determined.
MVD; no high levels of VEGF in LAL |
|
| Koomagi et al., Clin Cancer Res, 2001 [24] | C : 53 | BM (RT-PCR), diagnosis [25], relapse [22] | VEGF levels, outcome | VEGF correlated to better overall survival |
|
| Yetgin et al., Leukemia Lymphoma, 2001 [19] | C : 31 | Serum (VEGF & bFGF) (diagnosis and CR) | Correlations with prognosis criteria (HMG, WBC, Hb, platelets, phenotype) | Positive correlation, only with platelets |
|
| Pulè et al., Br J Hematol, 2002 [18] | C : 41 | BM (diagnosis and CR) | MVD & correlations with outcome (relapse) and prognosis criteria (age, sex, cytogenetics, phenotype) | No correlation |
|
| Schneider et al., Br J Hematol, 2003 [26] | C : 39 | Urine (diagnosis) | Levels of urinary bFGF and VEGF levels & outcome | bFGF and/or VEGF significantly associated with poor outcome |
|
| Wellmann et al., Leukemia, 2004 [27] | C : 18
C : 6 | BM (diagnosis)
Plasma (relapse) | Expression of VEGF & VEGF-R & HIF-1α by immunostaining; RT-PCR on BM-extracted RNA | VEGF and HIF-1α shorter DFS
VEGF if treatment resistance (MRD+) |
|
| Faderl et al. Blood, 2005 [17] | A : 95 | Plasma (diagnosis) | Relative risk of death (RR) according to VEGF levels | RR of death ×8 if VEGF <19.1 pg/mL |
|
| Avramis et al., Clinic Cancer Res, 2006 [28] | C : 17 | Serum (diagnosis, d14, d28) | Evolution of VEGF levels during induction; correlation with EFS | Positive predictive value of relapse if VEGF |
|
| Schneider et al., Leuk Res, 2007 [29] | C : 33 | Urine and plasma (diagnosis, relapse) | Levels of endostatin, bFGF, VEGF | plasma VEGF at relapse
No prognostic value of endostatin levels |
|
| Lyu et al., Yonsei Med J, 2007 [30] | C : 33 | BM Plasma (diagnosis and relapse) | Levels of VEGF & bFGF, correlations with WBC and age | Higher bFGF and VEGF levels in relapse. No correlations |
|
| Stachel et al., Oncology Reports, 2007 [31] | C : 46 | BM (diagnosis) | RT-PCR on BM-extracted RNA; correlations with relapse and survival | VEGF correlated to late relapse |
|
