Predicting the Kinetic Properties Associated with Redox Imbalance after Oxidative Crisis in G6PD-Deficient Erythrocytes: A Simulation Study

Figure 2

A pathway map of human red blood cell metabolism and antioxidant mechanism. The map is partially derived from Kinoshita et al. [19]. Gray boxes represent metabolites, and black boxes represent membrane transport or ion pump systems. Gray font indicates enzymes, and red font indicates the substrates or allosteric effectors of glycolytic enzymes. The blue region indicates the newly added pathway of reactive oxygen species (ROS) production and detoxification. Definitions of abbreviations for enzymes and metabolites can be found in the Supplementary Material.