Review Article
Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia
Table 1
The most common fusion partner genes of MLL: locations and functions.
| Partner gene | Location | Function |
| AF4 | 4q21 Nuclear | Leads to RNApol-II activation and to transcriptional elongation | AF9 | 9p22 Nuclear | In association with ENL, DOT1L, and AF4, activator of RNApol-II kinase p-TEFb | ENL | 19p13.3 Nuclear | Elongation factor. In association with AF9, DOT1L and AF4 activator of RNApol-II kinase p-TEFb | AF10 | 10p12 Nuclear | Transcriptional factor | ELL | 19p13.1 Nuclear | Elongation factor interacts with a nuclear protein related to AF4 | AF6 | 6q27 Cytoplasmatic | Multi-domain protein involved in signaling and organization of cell junctions during embryogenesis | AF1P | 1p32 Cytoplasmatic | Part of the EGFR pathway, involved in receptor-mediated endocytosis of EGF |
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p-TEFb: positive transcription elongation factor b. p-TEFb phosphorylates serine residues of the carboxy-terminal domain of RNApol-II; RNApol-II: RNA polymerase II; CTD: carboxy-terminal domain kinase; DOT1L: DOT1-like, histone H3 methyltransferase; EGFR: epidermal growth factor receptor; EGF: epidermal growth factor.
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