Review Article
Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia
Table 2
Cytogenetic molecular classification of adult ALL based on more recently published data.
| Risk group | Chromosomal/molecular aberrations | 5y-DFS | 5y-OS |
| STANDARD-RISK | Isolated 9p/p15-p16 deletions High hyperdiploidy Normal karyotype/no molecular aberrations | 35–68% | 48–80% |
| INTERMEDIATE-RISK | del(6q) Trisomy of chromosome 21 Trisomy of chromosome 8 t(1;19)/E2A-PBX | 37–51% | 35–40% |
| HIGH-RISK | t(9;22)/BCR-ABL t(4;11)/MLL-AF4 11q23 MLL rearrangements Monosomy of chromosome 7 Low hypodiploidy/near triploidy Complex karyotype High BAALC expression Aberrations of IKZF1 gene | 10–52% | 15–35% |
|
|
CR: complete remission; 5y-DFS: 5 years disease-free survival; 5y-OS: 5 years overall survival.
|