Expression of Thymidine Phosphorylase in Lymph Nodes Involved with Mycosis Fungoides and Sézary Syndrome
Figure 1
Immunohistochemical staining of thymidine phosphorylase (TP) expression and related markers in benign lymph node (a) and in lymph node with malignant mycosis fungoides/Sézary syndrome cells (LN-MF) (b–g). (a) In benign lymph node, TP expression highlights the meshwork of macrophages (arrow in inset; 400x) and endothelial cells (arrowhead in inset; 400x). (b) LN-MF: hematoxylin and eosin (H&E) stain. (c) CD3 highlights the malignant T cells and reactive T cells in LN-MF. (d) CD4 is weakly expressed in the malignant T cells in LN-MF. (e) CD68 highlights the macrophages in LN-MF. (f) CD21 is negative in this case of LN-MF. (g) TP highlights the macrophages (cytoplasmic/nuclear pattern, arrowhead in inset 1; 400x) and the malignant T cells (cytoplasmic pattern, arrow in inset 2; 400x) in a cytoplasmic staining pattern. Multiple mitotic figures are also noted in the malignant T cells. Images are from an Olympus BX41 microscope (Olympus Corp., Tokyo, Japan) processed with Qcapture Pro 5.1 (QImaging, Surrey, BC, Canada).
