Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia

Table 1

Summary of genetic mutations in JMML.

Gene	Site of mutation	Frequency
PTPN11	E76K, D61Y, D61V, E69K, A72T, A72V, E76V/G/A,	35%
RAS
NRAS	Codons 12 and 13	25%
KRAS	Codon 13
HRAS	No mutation in codons 12, 13, and 61 was found
NF1	Loss of wild-type NF1 allele	11–15%
CBL	Codons 371, 380, 381, 384, 396, 398, 404, and 408.	17%
	Splice sites 1227, 1228, and 1096