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Advances in Hematology
Volume 2012, Article ID 358518, 12 pages
http://dx.doi.org/10.1155/2012/358518
Review Article

Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish

1Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada B3H 3J5
2Departments of Pediatrics, Microbiology and Immunology, and Pathology, Dalhousie University, Halifax, NS, Canada B3H 3J5
3IWK Health Centre, Halifax, NS, Canada B3K 6R8
4Department of Haematology, UCL Cancer Institute, School of Life and Medical Sciences, University College London, London WC1E 6BT, UK

Received 20 April 2012; Accepted 5 June 2012

Academic Editor: Christopher Hall

Copyright © 2012 A. Michael Forrester et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture such haematopoietic cells continue to enhance our ability to use this simple organism to address disease biology. Coupled with the strengths of the zebrafish embryo to dissect developmental myelopoiesis and the continually expanding repertoire of models of myeloid malignancies, this versatile organism has established its niche as a valuable tool to address key questions in the field of myelopoiesis and myeloid leukaemogenesis. In this paper, we address the recent advances and future directions in the field of myelopoiesis and leukaemogenesis using the zebrafish system.