Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease

Figure 1

Gab structure and multiple binding sites. Gab molecules were originally identified as the mammalian homologs of the daughter of sevenless (DOS) drosophila adapter protein. Gab1, Gab2, and Gab3 share many common binding sites. All three Gabs have a PH domain in the amino-terminus that is believed to be essential for many functions including membrane localization. Gabs contain multiple binding sites and act as scaffolding molecules to support cytokine signaling. Binding sites for Grb2, Crk, PI3-K, and SHP-2 have been defined and extensively studied.