Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease

Table 1

Gabs are associated with multiple common hematopoietic receptors, RTK: receptor tyrosine kinase.

Receptor	Ligand	Cell type	Phosphorylated			References
			Gab1	Gab2	Gab3
RTK
Flt3	Flt3L	BaF3/Flt3, THP-1, RS4; 11	Yes	Yes	Yes	[7, 21]
Fms	M-CSF	FDFms, 32D-Fms, EML-Fms, BAC1.2F5, 32D, BMDM	NR	Yes	Yes	[6, 7, 22–26]
Kit	SCF	FDFms, MO7E, MC9, BMMC	Yes	Yes	NR	[23, 27–30]
Non-RTK
EPO receptor	EPO	BaF3, UT-7, HCD-57, primary erythroid cells, R1, Namalwa, FDC-P1	Yes	Yes	NR	[13, 31–34]
G-CSF receptor	G-CSF	BaF3, DT40	NR	Yes	NR	[35]
GM-CSF receptor	GM-CSF	FDFms, BaF3, UT-7	Yes	Yes	NR	[23, 36–38]
gp130	IL-6, LIF	HepG2, BAF-B03, T47D, MM.1S, cardiomyocytes	Yes	Yes	NR	[29, 39–43]
IL-15 receptor	IL-15	T cells, MyLa2059	NR	Yes	NR	[44, 45]
IL-2 receptor	IL-2	Kit225, KT-3, T-cell blasts, T cells, NK3.3, MyLa2059	NR	Yes	NR	[18, 19, 29, 45–47]
IL-3 receptor	IL-3	BaF3, BAF-B03, primary hematopoietic cells, NIH 3T3	Yes	Yes	Yes	[29, 48–53]
Mpl	TPO	TF-1, UT-7, BaF3, primary megakaryocyte progenitors	Yes	Yes	NR	[54–57]

NR: not reported.