Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease

Table 2

Gab1 and Gab2 are activated by kinases, oncoproteins, and other adaptors in cancer cells.

Cancer	Gab activator	Gab1	Gab2
Breast [79–83]	Amplification, ErbB2, Src	Yes	Yes
Glioblastoma [84]	Met	Yes	No
Thyroid [85]	Ret	Yes	No
Gastric [86]	Amplification	No	Yes
Myeloma [40]	Hck	Yes	Yes
Chronic myelogenous leukemia [53, 87]	Bcr/Abl	No	Yes
Friend virus erythroblastosis [16, 88]	Sf-Stk	No	Yes
Anaplastic large cell lymphoma [89]	NPM-Alk	No	Yes
Acute myeloid leukemia [90, 91]	Flt3-ITD	?	Yes
Myeloproliferative disease [92]	JAK2^V617F	?	Yes