Advances in Hematology / 2012 / Article / Tab 2

Review Article

Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease

Table 2

Gab1 and Gab2 are activated by kinases, oncoproteins, and other adaptors in cancer cells.

CancerGab activatorGab1Gab2

Breast [7983]Amplification, ErbB2, SrcYesYes
Glioblastoma [84]MetYesNo
Thyroid [85]RetYesNo
Gastric [86]AmplificationNoYes
Myeloma [40]HckYesYes
Chronic myelogenous leukemia [53, 87]Bcr/AblNoYes
Friend virus erythroblastosis [16, 88]Sf-StkNoYes
Anaplastic large cell lymphoma [89]NPM-AlkNoYes
Acute myeloid leukemia [90, 91]Flt3-ITD?Yes
Myeloproliferative disease [92]JAK2V617F?Yes

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.