Review Article
Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease
Table 2
Gab1 and Gab2 are activated by kinases, oncoproteins, and other adaptors in cancer cells.
| Cancer | Gab activator | Gab1 | Gab2 |
| Breast [79ā83] | Amplification, ErbB2, Src | Yes | Yes | Glioblastoma [84] | Met | Yes | No | Thyroid [85] | Ret | Yes | No | Gastric [86] | Amplification | No | Yes | Myeloma [40] | Hck | Yes | Yes | Chronic myelogenous leukemia [53, 87] | Bcr/Abl | No | Yes | Friend virus erythroblastosis [16, 88] | Sf-Stk | No | Yes | Anaplastic large cell lymphoma [89] | NPM-Alk | No | Yes | Acute myeloid leukemia [90, 91] | Flt3-ITD | ? | Yes | Myeloproliferative disease [92] | JAK2V617F | ? | Yes |
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