A Role for RNA Viruses in the Pathogenesis of Burkitt's Lymphoma: The Need for Reappraisal

Table 2

Arboviruses and Malaria—a comparison.

Characteristic	Arboviruses	Malaria
Epidemiology in Lymphoma Belt	Endemic and occasionally epidemic	Holoendemic + 3 types less intense
Age acquisition immunity	Mimics age distribution of eBL	By age of 5 yrs if holoendemic
Altitude Barrier	5000 ft at Equator, 3000 ft in Zambia—same as BL	Up to 8,000 ft at Equator
Geographic Distribution	Dependent on vectors—usually mosquitoes	Dependent on anopheline mosquitoes
Replication Temperature Requirements	Yellow fever stops <15.5–18°C	Malaria stops <20°C
	Same as BL	(PF > 18°C, PV > 17°C, PM > 16°C)
Effect malaria suppression	None	Reduced
Effect malaria eradication	Eradicated	Eradicated