Advances in Hematology / 2012 / Article / Tab 4

Review Article

Exploring Risk Factors for Follicular Lymphoma

Table 4

Environmental and lifestyle exposures associated with follicular lymphoma.

ExposureMeasure of Effect (95% CI) -trendReference

Alcohol

Highest category of beer consumption (drinks/week)HR = 0.90 (0.40–1.99)0.553[31]
Highest category of wine consumption (drinks/week)HR = 0.96 (0.49–1.90)0.513[31]
Highest category of liquor consumption (drinks/week)HR = 0.71 (0.30–1.69)0.395[31]
Highest category of alcohol consumption (drinks/week)HR = 0.71 (0.28–1.79)0.302[31]
Highest category of ethanol consumption (g/week)HR = 0.55 (0.24–1.30)0.295[31]
WineOR = 2.19 (0.83–5.80)[29]
Alcohol use (ever/never)OR = 1.22 (0.51–2.89)[68]
Survival: alcohol use <43.1 g/weekaHR = 0.35 (0.10–1.20)[80]
Survival: alcohol use >43.1 g/weekHR = 2.16 (0.98–4.77)[80]

Tobacco

Ever smokerHR = 0.62 (0.45–0.85)[31]
Current smokerHR = 0.74 (0.42–1.31)[31]
Former smokerHR = 0.59 (0.42–0.83)[31]
>30 years since quitting (former smokers)HR = 0.42 (0.21–0.84)0.374[31]
Age at initiation (>20)HR = 0.80 (0.47–1.34)0.318[31]
>40 years of having smokedHR = 0.52 (0.28–0.97)0.365[31]
Packs of cigarettes/dayHR = 0.59 (0.32–1.09)0.627[31]
Pack years of smoking >39.75 HR = 0.63 (0.37–1.07)0.949[31]
Ever smokerOR = 1.15 (1.02–1.29)[30]
Current smokersOR = 1.31 (1.12–1.52)[30]
Former smokersOR = 1.06 (0.93–1.22)[30]
Ever smokers >36 pack yearsOR = 1.30 (1.08–1.56)0.6[30]
Current heavy smokers > 36 pack yearsOR = 1.45 (1.15–1.82)0.85[30]
Survival: former smokerHR = 1.98 (0.81–4.80)[80]
Survival: current smokerHR = 2.95 (1.27–6.81)[80]
Survival: >17 pack-yearsHR = 2.61 (1.19–5.74)0.02[80]
Survival: time since quitting to diagnosis (<10 years versus never Smoker)HR = 3.73 (1.07–13.0)0.005[80]
ever smokerOR = 2.18 (0.75–6.35)[68]

Environmental exposures

UV exposure and Ex11 + 32 CC genotype: <7 hrs/wk sun exposure in last 10 yearsOR = 6.3 (1.9–22.0)0.004,
–interaction = 0.009
[62]
UV exposure and Ex11 + 32 CC genotype: <7 hrs/wk sun exposure in the fourth decadeOR = 5.7 (1.5–21)0.01,
-interaction = 0.003
[62]
UV exposure and Ex11 + 32 CC genotype: <7 hrs/wk sun exposure in the third decadeOR = 8.3 (1.9–37)0.03,
-interaction = 0.03
[62]
UV exposure and Ex11 + 32 CC genotype: <7 hrs/wk sun exposure in the second decadeOR = 20.0 (1.4–304)0.06,
-interaction = 0.05
[62]
Hair dyesOR = 1.33 (0.9–1.96)[69]
Hair dyesOR = 1.57 (0.72–3.46)[68]
All solventsOR = 1.3 (1.0–1.8)0.03[70]
BTX exposure (benzene, toluene, xylene)OR = 1.6 (1.0–2.5)0.08[70]
BenzeneOR = 1.6 (0.9–2.9)0.1[70]
Toluene OR = 1.5 (0.9–2.4)0.2[70]
XyleneOR = 1.6 (0.9–2.7)0.14[70]
CAH exposureOR = 1.1 (0.6–1.9)0.9[70]
TrichloroethyleneOR = 1.2 (0.6–2.3)0.65[70]
Gasoline exposureOR = 0.8 (0.5–1.5)0.3[70]
Chlorinated hydrocarbons, total > 47.3 ppm*yearsOR = 3.9 (1.3–12.1)0.04[71]
Trichloroethene > 35 ppm*yrsOR = 3.2 (0.8–12.9)0.16[71]
Tetrachloroethene > 0, <9.1OR = 1.2 (0.3–5.5)0.43[71]
CTET > 23, <48.1 ppm*yrsOR = 2.1 (0.2–19.4)0.83[71]
DCM > 26.3, <175 ppm*yrsOR = 1.5 (0.3–7.4)0.2[71]
Benzene > 130 ppm*yrsOR = 1.3 (0.3–6.4)0.51[71]
Toluene > 207 ppm*yrsOR = 1.1 (0.2–5.3)0.48[71]
Xylene > 230 ppm*yrsOR = 1.3 (0.3–6.2)0.33[71]
Styrene > 67.1 ppm*yrsOR = 1.6 (0.5–6.0)0.2[71]
Lived within 2 miles of a lumber and wood products facilitybOR = 1.1 (0.5–2.2)0.84[72]
Lived within 2 miles of a chemicals and allied products facilitybOR = 1.2 (0.8–1.8)0.34[72]
Lived within 2 miles of a petroleum refining and related industriesbOR = 1.1 (0.7–1.9)0.89[72]
Lived within 2 miles of a primary metal industries facilitybOR = 1.2 (0.8–1.7)0.21[72]
Lived within 100 m of high voltage power linesOR = 1.86 (0.75–4.63)[68]

aThe reference group consumes 0 g/week.
bPtrend is for half-mile increments within two miles proximity.

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