Genomic Amplification of an Endogenous Retrovirus in Zebrafish T-Cell Malignancies
Recurrent amplifications of a small genomic locus in zebrafish T-ALL. Ten kb loci on chromosomes 7 and 14 (Zv6 genomic assembly) show high-copy gains with multiple probes in these regions (black arrows) of 8/8 D. rerio T-ALL samples tested. Signal intensities above a “high-copy gain threshold” (upper green line) indicate a greater than 2-fold increase in copy number. Individual probes and their intensities are depicted as blue dots; areas with 3 adjacent probes above the high-copy gain threshold use green dots to denote those probes. Seven cancers exhibited high-copy signals for ≥5/6 probes in this region, while srk T-ALL3 had high-copy signals for only 2/6 probes.
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