Advances in Hematology / 2012 / Article / Fig 6

Research Article

In Vitro and In Vivo Antitumor Effect of Anti-CD33 Chimeric Receptor-Expressing EBV-CTL against Acute Myeloid Leukemia

Figure 6

Infiltration of tumors by EBV-CTLs. Forty-eight hours after i.v. administration of EBV-CTLs, tumors were resected, fixed in 10% formalin solution, and embedded in paraffin. CD8+ EBV-CTLs were detected by immunohistochemistry using an anti-CD8 antibody and reported in (a) unmodified EBV-CTLs, (b) CD33-EBV-CTLs. Genetically modified T cells were found at the periphery of the tumor in the vicinity of vessels (indicated as “V”), isolated or forming cluster (arrowheads or arrows, resp.).
683065.fig.006a
(a)
683065.fig.006b
(b)

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.