Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma

Table 1

Select lenalidomide-based, pre-ASCT induction regimens for NDMM.

RD	Lenalidomide 25 mg orally days 1–21 and dexamethasone 40 mg orally days 1–4, 9–12, 17–20. 28 day cycles [9]
Rd	Lenalidomide 25 mg orally days 1–21 and dexamethasone 40 mg orally weekly. 28 day cycles [9]
BiRD	Clarithromycin 500 mg orally twice daily continuously, starting on day 2 of cycle 1; lenalidomide 25 mg orally days 3–21 of cycle 1, then days 1–21 of later cycles; dexamethasone 40 mg orally days 1, 2, 3, 8, 15, and 22 of cycle 1, then days 1, 8, 15, and 22 of later cycles. 28 day cycles [10]
RVD	Lenalidomide 25 mg orally days 1–14; bortezomib 1.3 mg/m^2 IV days 1, 4, 8, 11; dexamethasone 20 mg orally days 1, 2, 4, 5, 8, 9, 11, 12. 21 day cycles [11]
CRD	Cyclophosphamide 300 mg (fixed dose) orally days 1, 8, and 15; lenalidomide 25 mg orally days 1–21; dexamethasone 40 mg orally days 1, 8, 15, 22. 28 day cycles [12]
RVCD	Lenalidomide 25 mg orally days 1–14; bortezomib 1.3 mg/m^2 IV days 1, 4, 8, 11; cyclophosphamide 500 mg/m^2 orally days 1 and 8; dexamethasone 40 mg orally days 1, 8, 15. 21 day cycles [13]
RVDDoxil	Lenalidomide 25 mg orally days 1–14; bortezomib 1.3 mg/m^2 IV days 1, 4, 8, and 11; dexamethasone 20 mg orally days 1, 2, 4, 8, 11, and 12 for cycles 1–4 and 10 mg on the same schedule for later cycles; liposomal doxorubicin 30 mg/m^2 IV on day 4. 21 day cycles [14]
CarRD	Carfilzomib 20–36 mg/m^2 days 1, 2, 8, 9, 15, 16; lenalidomide 25 mg orally days 1–21; dexamethasone 20–40 mg days 1, 8, 15, and 22. 28 day cycles (dose of carfilzomib and dexamethasone was variable in this phase 1/2 study) [15]