Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine

Table 2

IC₅₀ values of Ara-C, CNDAC, and mitoxantrone for HL-60 and THP-1 cell lines plated at (A) 0.05 × 10⁶ cells/mL and (B) 0.5 × 10⁶ cells/mL.

IC50values (μM)
	(A)	0.05 × 10^6 cells/mL			(B)	0.5 × 10^6 cells/mL
	Day	Ara-C	CNDAC	Mitoxantrone	Day	Ara-C	CNDAC	Mitoxantrone
HL-60	3	2.099	<0.5	<0.0025	3	6.157	5.356	0.021
	4	0.692	<0.5	<0.0025	4	5.031	1.149	0.011
	5	0.964	<0.5	<0.0025	5	5.503	<0.5	0.008
	6	1.929	<0.5	<0.0025	6	5.946	<0.5	0.003
THP-1	3	7.771	0.929	0.003	3	>10	>10	0.035
	4	>10	0.816	0.006	4	>10	2.774	0.030
	5	>10	1.105	0.011	5	>10	2.434	0.017
	6	>10	1.104	0.007	6	>10	2.095	0.012