Review Article
Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma
Table 1
“Crosstalk” between PC and BMSC.
| | Adhesion molecules | | Very late activation antigens-4 (VLA-4) | | Lymphocyte function-associated antigen-1 (LFA-1) | | Vascular cell adhesion molecule-1 (VCAM-1) | | Intercellular adhesion molocule-1 (ICAM-1) | | Syndecan-1 |
| | Cytokines | | Tumor necrosis factor-α (TNF-α) | | Transforming growth factor-β (TGF-β) | | Vascular endothelial growth factor (VEGF) | | Fibroblast growth factor-2 (FGF-2) | | Hepatocyte growth factor (HGF) | | Angiopoietin-1 (Ang-1) | | Interleukin-6 (IL-6) | | Insulin-like growth factor (IGF-1) |
| | Proteasi | | Matrix metalloproteinases -2 and -9 (MMP-2 e MMP-9) |
| | Chemokine | | Macrophage inflammatory protein-1 (MIP-1) | | Stromal derived factor-1 (SDF-1) |
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