Synergistic Effect of Anemia and Red Blood Cells Transfusion on Inflammation and Lung Injury
Figure 1
Effect of blood loss on systemic inflammation response and lung endothelial permeability. (a) Hct, (b) plasma IL-6, (c) plasma KC, and (d) plasma S1P were measured at baseline (time = 0; ) or at 24 () or 48 hours () after major blood loss (0.02 mL/gm). (e) Lung permeability was measured in mice that had not undergone blood loss (time = 0; ) or at 48 hours after major blood loss () by quantifying accumulation of IV injected EBD into the lung. Results were analyzed by one-way ANOVA (Bonferroni correction) * versus time = 0.