MicroRNAs as Haematopoiesis Regulators

Table 2

Proteins involved in miRNA biogenesis.

Gene	Description	Location	Function	Domains	Reference
Dicer	Dicer 1, ribonuclease type II	14q31	miRNA processing	Type 111 restriction enzyme, RNase3, DEAH, helicase, dsRBD, PAZ	[14]
AGO3	Argonaute 3	1p34-p34	Short-interfering-RNA-mediated gene silencing	PAZ, PIWI, DUF1785, DUF2344, DUF2678	[15]
Gemin3	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	1p13.2	RNA helicase	DEAD, Type 111 restriction enzyme, helicase C	[16]
Drosha	Drosha, ribonuclease type II	5p14-p13	Pri-miRNA processing	RNase3 domain, Double-stranded RNA binding motif	[17]
Exportin-5	Karyopherin family	6p21.1	Transport of small RNAs	Importin-beta N-terminal domain, exportin 1-like protein	[18]
FMRP	Fragile X mental retardation 1	Xq27.3	mRNA trafficking	KH domain	[19]
ADAR	Adenosine deaminase, RNA-specific	1q21.3	RNA and miRNA editing	z-Alpha, Dsrm, Editase	[20]
TRBP	TAR (HIV-1) RNA binding protein	12q12, q-13	Dicer stabilization	DZF, dsRBD	[21]
Importin-8	GTPase Ran mediate nuclear import	12p11.21	Nuclear localization of Argonaute proteins	Cse1	[22]
ELAV1	(Embryonic lethal, abnormal vision, Drosophila-like 1)	19p13.2	Repression of target sites	RBD	[23]
Dnd1	Dead end homolog 1	5q31.3	Inhibiting miRNA-mediated repression	PMP-22	[24]