Table 2: Proteins involved in miRNA biogenesis.

GeneDescriptionLocationFunctionDomainsReference

DicerDicer 1, ribonuclease type II14q31miRNA processingType 111 restriction enzyme, RNase3, DEAH, helicase, dsRBD, PAZ[14]

AGO3Argonaute 31p34-p34Short-interfering-RNA-mediated gene silencingPAZ, PIWI, DUF1785, DUF2344, DUF2678[15]

Gemin3DEAD (Asp-Glu-Ala-Asp) box polypeptide 201p13.2RNA helicaseDEAD, Type 111 restriction enzyme, helicase C[16]

DroshaDrosha, ribonuclease type II5p14-p13Pri-miRNA processingRNase3 domain, Double-stranded RNA binding motif[17]

Exportin-5Karyopherin family6p21.1Transport of small RNAsImportin-beta N-terminal domain, exportin 1-like protein[18]

FMRPFragile X mental retardation 1Xq27.3mRNA traffickingKH domain[19]

ADARAdenosine deaminase, RNA-specific1q21.3RNA and miRNA editingz-Alpha, Dsrm, Editase[20]

TRBPTAR (HIV-1) RNA binding protein12q12, q-13Dicer stabilizationDZF, dsRBD[21]

Importin-8GTPase Ran mediate nuclear import12p11.21Nuclear localization of Argonaute proteinsCse1[22]

ELAV1(Embryonic lethal, abnormal vision, Drosophila-like 1)19p13.2Repression of target sitesRBD[23]

Dnd1Dead end homolog 15q31.3Inhibiting miRNA-mediated repressionPMP-22[24]