MicroRNAs as Haematopoiesis Regulators

Table 5

miRNAs involved in erythropoiesis.

MiRNA	Function	Putative targets	Reference
miR-144, miR-451	Erythroid homeostasis, deficiency leads to splenomegaly, mild anaemia, and erythroid hyperplasia, controlled by GATA1	TSPAN12, HMGCR, FBN2, MAP3K8, CXCL16, EREG, ATF2, CDKN2B	[54, 55]
miR-451	Erythroid differentiation defect and reduction in haematocrit in miRNA-451^−/− mice	CDKN2B, CXCL16, EREG, ATF2	[56]
miR-223	Reduces the commitment of erythroid progenitors	LIN54, FOXO1, USP42, ALCAM, BCLAF1, SLC11A2	[57, 58]
miR-15b, mi16, miR-22	Positive correlation with erythroid markers CD36, CD235a, and CD71	PRDM4, KIF1B, LAMP3, SWAP70, LIN7C, AKT3, LAMC1	[59, 60]
miR-28	Negatively correlate with CD71		[59, 60]
miR-320	Favours CD71 transcriptional activities		[60]
miR-221, miR-222	Inhibit normal erythropoiesis	TAF9B, MYLIP, RAB18, CYP7A1, KIF16B, MAT2A, NXN	[61]
miR-24	Targets ALK4	TRIB3, CBX5, KCNJ2, DGA52	[62]
miR-15a	Transition from BFU-E to CFU-E stage	GFAP, SLC9A8, ZNRF2, FAM81A	[63]