MicroRNAs as Haematopoiesis Regulators

Table 6

miRNAs involved in AML.

miRNA	Function	Putative targets	Reference
miR-126*	Upregulation leads to chromosomal translocations and inhibits apoptosis	ADAT2,FOF1, LMO7,	[64]
miR-126	Targets tumour suppressor PLK2	TOM1, CKMT2, ZNF131, RGS3,	[64]
miR-223	C/EBPα regulates its expression in turn it inhibits E2F1 in AML cells	ANKH, SCN1A, SCN3A, CBFB, CDH11, NEBL, RILPL1, CENPN	[65]
miR-221	Oncogenic miRNA, it inhibits the CDK inhibitor p27	HIPK1, RAB18, DNM3, ZNF547,	[66]
miR-124a	Target the C/EBPα, silenced and block differentiation gives leukemia phenotype		[67]
miR-20a and miR-17	Inhibits the p21	POLQ, KLF12, STK38, CENTD1, NUP35, GNB5, CTSK	[68]
miR-29b	Tumour suppressor in AML and reduce tumorigenicity	SCML2, C1orf96, COL3A1, COL7A1, COL11A1	[69]
miR-29b	Reduced expression of DNA methyltransferases	CD93, HBP1, SNX21, GNS, HMGCR, HNF4G, DNMT3B	[69]
miR-196a and miR-196b	They target ERG expression	FOS, GATA6, HOXB6, HOXC8, ZNF24, CCDC47	[70]
miR-193b	Downregulated in AML and it targets c-Kit	MMP19, ARMC1, ARPC5	[71]