MicroRNAs as Haematopoiesis Regulators

Table 7

miRNAs involved in CML.

miRNA	Function	Putative targets	Reference
miR-17-92	Down-regulated in imatinib treated CML cells	IRF9, RAB10, TXNIP, TET2	[72]
miR-21	Antisense inhibition leads to inhibition of migration and cell growth and induces apoptosis	TXPAN2, LUM, SUZ12, MSH2, PDZD2	[73]
miR-203	Methylated in AML, CML, ALL, CLL. Inhibit the expression of BCR-ABL	RTKN2, AAK1, MYST4 CD109, IL21, PLD2	[74]
miR-451	Associated with Bcr-Abl	TSC1, ACADSB, GRSF1, MAML1, GDI1, NAMPT	[75]
miR-29b	Inhibits ABL1 and BCR/ABL1 there by inhibiting cell growth and colony formation	HAS3, SNX24, CD93, SCML2, COL7A1, ZNF396, HMGCR, ICOS	[76]
miR-138	Represses BCR/ABL1 and CCND3, increases by GATA1	KLF12, H3F3B, MYO5C, NXN, NEBL, PDPN, STK38	[77]
miR-212	Increases the ABCG2 expression	APAF1, EP300, EDNRA, CFL2, NOS1, SOX4, SOX11	[78]