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Advances in Hematology
Volume 2014 (2014), Article ID 369084, 5 pages
Clinical Study

Determining Risk Factors of Bleeding in Patients on Warfarin Treatment

1Department of Emergency Medicine, Silifke State Hospital, Mersin, Turkey
2Department of Emergency Medicine, Faculty of Medicine, Mersin University, Mersin, Turkey
3Department of Biostatistics, Faculty of Medicine, Mersin University, Mersin, Turkey
4Department of Emergency Medicine, Tepecik Research Hospital, İzmir, Turkey
5Department of Emergency Medicine, State Hospital, Niğde, Turkey
6Department of Emergency Medicine, State Hospital, Balıkesir, Turkey

Received 4 June 2014; Revised 3 October 2014; Accepted 21 October 2014; Published 9 November 2014

Academic Editor: Elvira Grandone

Copyright © 2014 Evren Uygungül et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Warfarin is a commonly used oral anticoagulant agent. The most common adverse effects of warfarin are bleeding complications. Methods. We performed a 1-year retrospective chart review of emergency department patients using warfarin. A total of 65 patients with bleeding disorder (study group) and 63 patients without bleeding (control group) were included, making up a total of 128 subjects. Demographic data, frequency of international normalized ratio (INR) checks, and routine blood results were extracted. Logistic regression analysis was used to determine which factors were most closely associated with bleeding complications. Results. Median age was and for study group and control group, respectively. Educational status and frequency of INR checks were similar in both groups ( and , resp.). INR levels were higher in the study group ( versus , ). Creatinine levels were also higher in the study group ( mg/dL versus  mg/dL, ). Acetylsalicylic acid use was more frequent in the study group and was associated with a 9-fold increase in bleeding complications . Conclusions. High INR levels, high creatinine levels, and acetylsalicylic acid use were associated with bleeding complications in ED patients using warfarin.