Haploidentical Transplantation in Children with Acute Leukemia: The Unresolved Issues

Table 1

Outcome of T cell depleted haploidentical transplantation for children with acute leukemia.

Ref.	Patients with AL (total)	Age range (years)	Disease status	Conditioning	Graft manipulation	Graft composition		Engraftment (%)	Acute GVHD (%)	Chronic GVHD (%)	NRM (%)	Relapse (%)	Overall survival (%)
						CD34; (×10^6)	CD3; (×10^7)
Aversa et al. (1998) [17]	43	4–53	Advanced	FLU/TT/ATG/TBI	CD34 selection	14	2.7	95.3%	None	None	40%	AML: 13%; ALL: 63%	AML: 36%; ALL: 17%
Handgretinger et al. (2001) [18]	21 (39)	(0.5–18)	NR = 9; CR = 12	MA	CD34 selection	20.7	1.5	92.3%	5%	None	28%	33%	NR: 14%; CR: 39%
Goldman et al. (2000) [39]	52	1–19	AML; Rel./Ref.	TBI: 40; Non-TBI: 12	Bone marrow; CD2 depletion	MNC×10^8	3.04	71%	44%	None	71%	26%	2%
Ortín et al. (2002) [23]	16 (21)	2–16	CR	CY/TBI	CD34 selection	8.5	5.6	100%	43%	25%	4.8%	18.7%	81.3%
Marks et al. (2006) [22]	34	1–16	CR 18; NR 16	CY/TBI/Campath/ATG	CD34 selection	13.8	0.3–5.2	91.7%	29%	12%	29.4%	CR: 13%; NR: 100%	26%; AML CR: 28%; ALL CR: 38%
Klingebiel et al. (2010) [24]	127	0.6–16	ALL; NR 25; CR 102	MA	CD34 selection	12.3	5.0	91%	37%	16.7%	37%	36%	CR: 22–39%; NR: 0%
Leung et al. (2011) [38]	38	<16	NR 5; CR 30	TBI: 20Non-TBI: 15	CD34 selection: 13; CD3 depletion: 17; Others: 5	NA	9–44	NA	25.7%	NA	23.9%	14.7%	<2002: 19%; >2002: 88%
Lang et al. (2014) [36]	46	1.1–23.7	NR 20; CR 26	FLU/TT/MEL; +ATG/OKT3	CD3/19 depletion	14.5	0.59	81.6%	26%	21%	10.8%	38%	CR: 31%; NR: 20%
Lang et al. (2015) [43]	29 (41)	<16	NR 9; CR 20	NA	TCRα/β  and CD3 depletion	14.9	1.69	88%	24%	18%	NA%	47.2%	CR1–CR3: 100%; NR: 0%

AL: acute leukemia; ALL: acute lymphoblastic leukemia; AML: acute myeloid leukemia; ATG: antithymocyte globulin; CR: complete remission; CY: cyclophosphamide; GVHD: graft-versus-host disease; FLU: Fludarabine; MA: myeloablative conditioning; Mel.: Melphalan; NR: not in remission; NRM: nonrelapse mortality; Ref.: refractory; Rel.: relapsed; TBI: total body irradiation; TT: thiotepa.