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Advances in Hematology
Volume 2016, Article ID 3905907, 16 pages
Review Article

Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies

1Department of Haematology, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK
2Kings College London, Kings College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK
3Department of Haematology, Guys and St. Thomas’ NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK

Received 15 December 2015; Revised 28 March 2016; Accepted 4 April 2016

Academic Editor: Suparno Chakrabarti

Copyright © 2016 Kevon Parmesar and Kavita Raj. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Haematopoietic stem cell transplantation is a well-established treatment option for both hematological malignancies and nonmalignant conditions such as aplastic anemia and haemoglobinopathies. For those patients lacking a suitable matched sibling or matched unrelated donor, haploidentical donors are an alternative expedient donor pool. Historically, haploidentical transplantation led to high rates of graft rejection and GVHD. Strategies to circumvent these issues include T cell depletion and management of complications thereof or T replete transplants with GVHD prophylaxis. This review is an overview of these strategies and contemporaneous outcomes for hematological malignancies in adult haploidentical stem cell transplant recipients.