Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies

Figure 2

Illustration of three types of NIMA-complementary HLA haploidentical stem cell transplants: A, B, and C. Transplantation from mother to offspring (A) causes a graft versus host (GVH) reaction against the inherited paternal antigen (IPA) and a host versus graft (HVG) reaction against the NIMA of offspring 1 (Mb). Transplantation from offspring to mother (B) causes a GVH reaction against the NIMA of offspring 2 (Ma) and HVG reaction against the inherited paternal antigen (IPA). Transplantation between NIMA-mismatched siblings with a shared IPA (C) involves bidirectional mismatch for the NIMA and bidirectional GVH/HVG reactions. Adapted from Ichinohe et al. [63].