Reference Donor type ( ) Anti-HLA abs test Desensitization method MFI after treatment Graft outcome
Barge et al. 1989 [41 ] Haplo ( ) CDC Plasmapheresis NA Graft failure
Maruta et al. 1991 [52 ] Mismatched related ( ) AHG-CDC CyA, methylpred, Plasmapheresis, DLI Negative XM Engrafted
Braun et al. 2000 [53 ] Haplo ( ) FCXM Staphylococcal protein A immunoadsorption Negative XM Engrafted
Ottinger et al. 2002 [20 ] Mismatched related ( ) DTT-CDC Plasmapheresis, mismatched platelet transfusion 1 patient with negative XM, 1 patient with positive XM Patient with negative XM after treatment engrafted, while patients with positive XM had GF
Pollack and Ririe 2004 [54 ] Mismatched HLA-A68 related ( ) FCXM Platelet transfusion, plasmapheresis, IVIg Negative XM Engrafted
Narimatsu et al. 2005 [55 ] Mismatched related ( ) AHG-LCT Rituximab, platelet transfusion Negative AHG-LCT Engrafted Ciurea et al. 2009 [22 ] Haplo ( ) Luminex MFI >500 Rituximab, plasmapheresis 1 negative, 1 low titer, 2 high titers Patients with DSAs negative and low titer after treatment engrafted; 2 patients with high titer had GF Yoshihara et al. 2012 [48 ] Haplo ( ) Luminex MFI >500 Plasmapheresis + rituximab ( ), platelet transfusion ( ), bortezomib + dexa ( ) 1 patient had temporary DSA reduction and 1 patient had significant reduction after plasmapheresis; 2 patients had a significant reduction post platelet transfusion; 1 patient had moderate DSA reduction after bortezomib and dexa All patients engrafted Ciurea et al. 2015 [46 ] Haplo ( ) Luminex MFI >500 Plasmapheresis + rituximab + IVIg ( ), PE + rituximab + IVIg + donor buffy coat infusion ( ) No significant change of MFI before transplant All patients cleared DSA after transplant 5 patients with C1q positive after treatment had GF while patients who became C1q negative engrafted
Leffell et al. 2015 [56 ] Haplo ( ) MMUD ( ) Luminex MFI >1000 Plasmapheresis + IVIg Mean reduction of DSAs after treatment was 64.4%. 1 patient failed to reduce DSAs to the level that was thought to be safe for transplant All 14/14 transplanted patients engrafted