Research Article
Vitamin D and Nonskeletal Complications among Egyptian Sickle Cell Disease Patients
Table 3
Demographic and laboratory data of the 2 groups.
| | Variable | Normal Group (n=32) | Deficient Group (n=48) | P-value |
| | Age: in years:median (IQR) | 8 (9.235) | 11(5) | 0.043 |
| | Sex: n (%) | | | 0.732 | | Male (%) | 17 (53.1%) | 30 (62.5%) | | | Female (%) | 15 (46.9%) | 18 (37.5%) | |
| | Weight percentile: mean ± SD | 29.7±20.2 | 22.1±18.2 | 0.072 |
| | Height percentile: mean ± SD | 33.8±26.5 | 22.2±24.8 | 0.024 |
| | Hemoglobin genotype: n (%) | | | 0.635 | | HBSS (%) | 26 (81.3%) | 33 (68.7%) | | | HBSB+ (%) | 5 (15.6%) | 11 (20.8%) | | | HBSB0 (%) | 1 (3.1%) | 4 (10.5%) | |
| | Splenomegaly: n (%) (n= 28) | 12 (37.5) | 16 (33.4) | 0.655 |
| | Splenectomy: n (%) (n=22) | 7 (31.8) | 15 (68.2) | 0.156 |
| | Pallor: n (%) (n=38) | 12 (31.5) | 26 (68.5) | 0.267 |
| | Jaundice: n (%) (n=21) | 1 (4.8) | 20 (95.2) | 0.001 |
| | Osseous changes: n (%) (n=13) | 3 (23) | 10 (76) | 0.015 |
| | Hemoglobin (g/dL): mean ± SD | 8.6±1.1 | 7.9±1.6 | 0.022 |
| | Hematocrit (%): mean ± SD | 26.9±4 | 23.9±5.1 | 0.004 |
| | Reticulocyte count (%): mean ± SD | 4.8±2.9 | 6.5±4.1 | 0.063 |
| | Corrected Reticulocyte count (%): mean ± SD | 2.6±1.4 | 3±2.1 | 0.401 |
| | AST (IU/L): mean ± SD | 43.3±23.3 | 54.4±20.1 | 0.006 |
| | ALT (IU/L): mean ± SD | 25.1±20.3 | 27.1±18.8 | 0.540 |
| | LDH (IU/L): mean ± SD | 454.8±279.4 | 634.9±277.8 | 0.001 |
| | TSB (mg/dL): mean ± SD | 4.2±2.4 | 5.9±3.5 | 0.038 |
| | Indirect bilirubin (mg/dL): mean ± SD | 2±1.8 | 2.6±1.4 | 0.016 |
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n = number. IQR = interquartile range. SD = standard deviation. HBSS= homozygous hemoglobin S; HBSβ+ = Sβ+ thalassemia; HBSβ0 = Sβ0 thalassemia; AST = aspartate aminotransferase; ALT = alanine aminotransferase; LDH = lactate dehydrogenase; TSB = total serum bilirubin. Bold values indicate statistical significance.
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