Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes

Table 5

The ratio of FOXP3 exon 2 fluorescence intensity to FOXP3 total fluorescence intensity in CD3⁺CD4⁺FOXP3⁺ cells from the peripheral blood of the patients with MDS and age-matched healthy donors.

Group	FI (FOXP3 exon 2/total), a.u.^4
Age control, n=26	0.52 (0.48–0.56)
MDS-primary^1, n=21	0.68 (0.59–0.75)
E-MDS^2, n=27	0.56 (0.47–0.65)
L-MDS^3, n=28	0.54 (0.47–0.62)

-primary: primary myelodysplastic syndrome; ²E-MDS: early-stage myelodysplastic syndrome; ³L-MDS: late-stage myelodysplastic syndrome; ⁴a.u.: arbitrary units. Note: p<0.001 rel. to age control; p<0.05 rel. to MDS-primary; p <0.001 rel. MDS-primary.