Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia

Table 3

Frequency of pain in patients with SCA.

Frequency of pain	Placebo group			Study group			p-value
	M0	M2	M4	M0	M2	M4
Never, n ()	7 (28)	7 (28)	7 (28)	6 (24)	6 (24)	6 (24)	0,027
Every year, n ()	3 (12)	3 (12)	3 (12)	13 (52)	13 (52)	13 (52)
Every month, n ()	7 (28)	7 (28)	7 (28)	3 (12)	3 (12)	5 (20)
Every week, n ()	2 (8)	2 (8)	3 (12)	0 (0)	0 (0)	1 (4)
Every day, n ()	6 (24)	6 (24)	5 (20)	3 (12)	3 (12)	0 (0)

Chi-square test: M0 (timepoint before receiving placebo or L-arginine supplement); M2 (timepoint two months after receiving placebo or L-arginine supplement); M4 (timepoint four months after receiving placebo or L-arginine supplement).