Blood Donors’ Age, Haemoglobin Type, G6PD Status, and Blood Group Impact Storability of CPDA-1 Banked Whole Blood: A Repeated-Measure Cohort Study in Cape Coast, Ghana

Table 2

Stratification based on inherited haemoglobin variants of donor blood unit.

Variable	Days					value
	Day 0	Day 7	Day 14	Day 21	Day 35
Plasma K+ levels
Hb A	4.040	10.040	14.680	17.620	23.760	<0.0001
Hb AC	4.140	10.480	15.330	17.970	25.440	<0.0001
Hb AS	4.040	9.840	14.200	16.750	23.870	<0.0001
value	ns	ns	ns	ns	ns
Osmotic-induced lysis
Hb A	ND	82.980	55.690	40.550	53.120	<0.0001
Hb AC	ND	26.820	12.210	11.110	16.870	0.0083
Hb AS	ND	73.720	40.120	31.430	45.970	<0.0001
value		<0.0001	<0.0001	<0.0001	<0.0001
% free haemoglobin
Hb A	ND	0.000	0.000	0.609	0.910	<0.0001
Hb AC	ND	0.000	0.281	0.323	0.914	0.0015
Hb AS	ND	0.000	0.197	0.275	0.762	0.018
value		ns	ns	ns	ns

ND means not determined; ns means not significant; median value significantly differed from day 0 (K+ levels), or day 7 (for osmotic fragility or % free haemoglobin); ns means not statistically significantly different; statistical significance was estimated per haemoglobin variant in relation to days of storage by means of Friedman’s repeated measure test with Dunn’s multiple correction; across the three haemoglobin variants, statistical differences within each day were calculated using the Kruskal–Wallis test.