|
| | Apixaban [59] | Edoxaban [60, 61] | Rivaroxaban [62, 63] | Betrixaban [64] | Dabigatran [37, 65] |
|
| Prothrombin time (PT) | Linear/ curvilinear correlation | Linear, concentration-dependent, Poor sensitivity at low drug levels | Weak correlation at increasing concentrations | Concentration-dependent correlation at on-therapy range, Low sensitivity | Poor correlation, Low sensitivity |
|
| Activated partial thromboplastin time (aPTT) | Weak correlation, poor sensitivity | Fair concentration- dependent correlation | Poor to moderate concentration- dependent correlation | Concentration-dependent correlation, Low sensitivity | Degree of prolongation poorly correlated with concentration |
|
| Anti-factor Xa assay | Linear variation, decreased correlation at lower concentrations | Linear, concentration-dependent correlation | Linear, concentration- dependent correlation | Concentration-dependent correlation | — |
|
| Thrombin time | — | — | — | — | Normal TT effective in excluding significant dabigatran presence, highly sensitive |
|
| Dilute thrombin time | — | — | — | — | Strong correlation within on-therapy range |
|
| Ecarin based-assay | — | — | — | — | Strong, linear correlation within on-therapy range, highly sensitive |
|
