Research Article
Thrombophilic Risk of Factor V Leiden, Prothrombin G20210A, MTHFR, and Calreticulin Mutations in Essential Thrombocythemia Egyptian Patients
Table 1
Statistical analysis of haemogram, coagulation profile tests, and thrombophilia gene in essential thrombocythemia patients versus control groups.
| | | Type | Mean ± SD or n (%) | |
| | HG (gm/dl) | Control (40) | 11.800 ± 1.4571 | 0.055 | | Patients (120) | 10.614 ± 2.4959 |
| | Hematocrit (%) | Control (40) | 41.8000 ± 3.41205 | 0.17 | | Patients (120) | 38.8250 ± 9.41871 |
| | WBCs (×109/L) | Control (40) | 6.200 ± 1.2424 | 0.001 | | Patients (120) | 10.883 ± 4.9132 |
| | PLT (×109/L) | Control (40) | 262.25 ± 93.346 | 0.001 | | Patients (120) | 991.75 ± 428.410 |
| | PT (sec) | Control (40) | 11.510 ± 0.9856 | 0.003 | | Patients (120) | 12.600 ± 0.3097 |
| | APTT (sec) | Control (40) | 32.40 ± 2.722 | 0.06 | | Patients (120) | 30.25 ± 4.754 |
| | Fibrinogen concentration (mg/dl) | Control (40) | 257.60 ± 6.7 | 0.001 | | Patients (120) | 378.13 ± 35.766 |
| | Factor V Leiden (Heterozygous) | Control (40) | 4 (10) | 0.007 | | Patients (120) | 54 (45) |
| | Prothrombin gene mutation (heterozygous) | Control (40) | 8 (20) | 0.8 | | Patients (120) | 27 (22.5) |
| | MTHFR mutation | Control (40) | 10 (25) | <0.001 | | Patients (120) | 93 (77.5) |
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