Haptoglobin Gene Polymorphism among Sickle Cell Patients in West Cameroon: Hematological and Clinical Implications

Table 4

Hematological parameters among the study groups.

Group	SS	AS	AA	value
WBC (×10^9/L)	18.06 ± 8.45^a	7.55 ± 3.96^b	6.19 ± 1.81^b	≤0.001^∗
Lymph (×10^9/L)	8.38 ± 4.68^a	3.50 ± 2.29^b	2.85 ± 0.94^b	≤0.001^∗
Mon (×10^9/L)	1.89 ± 0.85^a	0.78 ± 0.52^b	0.57 ± 0.21^c	≤0.001^∗
Gran (×10^9/L)	7.79 ± 5.23^a	3.26 ± 1.57^b	2.77 ± 1.04^b	≤0.001^∗
Lymph%	46.2 ± 10.5^a	45.5 ± 8.6^a	46.3 ± 8.4^a	0.880
Mon%	10.9 ± 3.5^a	10.4 ± 3.2^a,b	9.3 ± 2.3^b	≤0.005^∗
Gran%	42.8 ± 10.8^a	44.0 ± 8.6^a	44.4 ± 8.6^a	0.523
Hb (g/dL)	7.49 ± 1.32^c	11.66 ± 2.03^b	12.5 ± 1.10^a	≤0.001^∗
RBC (×10^12/L)	2.98 ± 0.68^c	4.77 ± 0.84^b	5.08 ± 0.43^a	≤0.001^∗
HCT (%)	27.0 ± 5.0^c	40.5 ± 6.6^b	43.0 ± 3.36^a	≤0.001^∗
MCV (fL)	91.1 ± 12.8^a	85.7 ± 8.1^b	85.0 ± 5.6^b	≤0.001^∗
MCH (pg)	25.64 ± 3.05^a	24.55 ± 2.32^b	24.46 ± 2.17^b	≤0.001^∗
MCHC (g/dL)	27.91 ± 1.50^b	28.69 ± 0.86^a	28.99 ± 0.72^a	≤0.001^∗
RDW-CV%	23.4 ± 3.4^a	16.2 ± 3.9^b	14.3 ± 1.2^c	≤0.001^∗
RDW-SD (fL)	76.5 ± 13.4	50.5 ± 11.9	45.7 ± 4.3	≤0.001^∗
PLT (×10^9/L)	469 ± 181^a	333 ± 150^b	283 ± 78^b	≤0.001^∗
MPV (fL)	9.83 ± 0.67^b	10.14 ± 0.66^a	10.05 ± 0.84^a,b	≤0.05^∗
PDW	14.7 ± 0.3	14.5 ± 0.2	14.6 ± 0.2	0.175
PCT%	7.51 ± 0.9	0.31 ± 0.09	0.28 ± 0.07	0.522

WBC: white blood cells; RDW: red cell distribution width; PDW: platelet distribution width; PCT: platelet crit; a, b, and c: values with different letters in the same line are significantly different at  < 0.05; ANOVA with post hoc Dunnet T3.