Haptoglobin Gene Polymorphism among Sickle Cell Patients in West Cameroon: Hematological and Clinical Implications

Table 5

Haptoglobin genotype and allele frequency distribution in the study population.

Groups		SS (n = 102)	AS (n = 55)	AA (n = 60)	value
Hp genotypes	Hp 1-1	32 (31.4%)^a	16 (29.1%)^a,b	21 (35%)^a,b	≤0.001^∗
	Hp 2-1	15 (14.7%)^b	23 (41.8%)^a	23 (38.3%)^a
	Hp 2-2	55 (53.9%)^a	16 (29.1%)^b	16 (26.7%)^b
	Hp1S-1S	25 (24.5%)^a,b	8 (14.5%)^a	9 (15%)^a	≤0.001^∗
	Hp1F-1F	6 (5.9%)^a,b,c	6 (10.9%)^a	9 (15%)^a
	Hp1S-1F	1 (1%)^a,b,c	2 (3.6%)^a	3 (5%)^a
	Hp2-1S	11 (10.8%)^a,c	13 (23.6%)^a	13 (21.7%)^a
	Hp2-1F	4 (3.9%)^c	10 (18.2%)^a	10 (16.7%)^a
	Hp2-2	55 (53.9%)^a,b	16 (29.1%)^a	16 (26.7%)^a
Hp allele frequencies	Hp^1S	0.304	0.282	0.283
	Hp^1F	0.084	0.218	0.258
	Hp^2	0.613	0.5	0.458

a, b, and c: values with different letters in the same line are significantly different at  < 0.05; SD: standard deviation; ∗: chi² test with the Bonferroni adjustment and Fischer test for small size groups.