Haptoglobin Gene Polymorphism among Sickle Cell Patients in West Cameroon: Hematological and Clinical Implications

Table 6

Variation of hematological profile according to the Hp genotype in SS patients.

Parameters	Hp 1S-1S	Hp 1F-1 F	Hp 1S-1 F	Hp 2-1S	Hp 2-1F	Hp 2-2	value
Number of individuals	25 (24.5%)	6 (5.9%)	1 (1%)	11 (10.8%)	4 (3.9%)	55 (53.9%)
Hb (g/dL)	7.19 ± 1.03	8.23 ± 2.62	8.90	7.54 ± 1.33	7.62 ± 0.70	7.49 ± 1.30	0.532
WBC (×10^9/L)	17.12 ± 6.24	16.95 ± 4.47	11.90	20.89 ± 13.28	15.22 ± 4.74	18.33 ± 8.82	0.764
RBC (×10^12/L)	2.94 ± 0.75	3.42 ± 1.25	3.20	3.02 ± 0.56	2.97 ± 0.48	2.94 ± 0.62	0.737
Lymph (×10^9/L)	8.42 ± 4.26	8.51 ± 2.91	6.50	7.43 ± 1.74	6.17 ± 1.95	8.76 ± 5.56	0.877
Mon (×10^9/L)	1.76 ± 0.76	1.66 ± 0.85	1.10	1.93 ± 0.70	1.45 ± 0.47	2.01 ± 0.94	0.570
Gran (×10^9/L)	6.92 ± 2.71	6.76 ± 1.71	4.30	11.51 ± 12.46	7.60 ± 4.04	7.55 ± 3.79	0.223
Lymph%	48.5 ± 10.4	49.4 ± 8.2	54.6	40.6 ± 11.9	41.9 ± 15.2	46.5 ± 10.0	0.300
Mon%	10.7 ± 3.8	9.6 ± 2.7	9.0	10.4 ± 3.9	9.5 ± 1.5	11.5 ± 3.5	0.659
Gran%	40.8 ± 9.7	41.0 ± 8.6	36.4	49.0 ± 13.3	48.6 ± 16.0	42.0 ± 10.3	0.269
HCT (%)	26.33 ± 5.58	29.43 ± 7.97	30.60	26.81 ± 5.08	27.95 ± 3.05	26.99 ± 4.75	0.798
MCV (fL)	91.25 ± 11.17	88.50 ± 9.53	95.90	89.13 ± 7.20	94.95 ± 8.50	91.29 ± 15.25	0.965
MCHC (g/dL)	28.30 ± 1.72	27.73 ± 3.21	29.0	28.18 ± 1.23	27.30 ± 1.02	27.70 ± 1.22	0.586
PLT (×10^9/L)	458 ± 175	451 ± 307	551	454 ± 202	608 ± 169	463 ± 166	0.733
MPV (fL)	9.92 ± 0.63	9.91 ± 0.50	9.20	10.03 ± 0.56	9.75 ± 0.50	9.76 ± 0.75	0.720
MCH (pg)	25.85 ± 3.85	24.36 ± 2.79	27.80	25.03 ± 2.21	25.85 ± 2.37	25.77 ± 9.96	0.828
RDW-CV%	23.4 ± 3.2	22.7 ± 5.6	19.0	23.3 ± 2.9	22.2 ± 1.2	23.8 ± 3.5	0.727
RDW-SD (fL)	75.6 ± 14.8	73.1 ± 20.7	66.1	74.4 ± 8.3	74.3 ± 9.2	78.0 ± 13.4	0.837
PDW	14.7 ± 0.4	14.6 ± 0.2	14.1	14.7 ± 0.2	14.6 ± 0.2	14.7 ± 0.4	0.591
PCT%	0.42 ± 0.10	0.37 ± 0.24	0.51	0.39 ± 0.08	0.47 ± 0.19	0.43 ± 0.14	0.809

WBC: white blood cells; RDW: red cell distribution width; PDW: platelet distribution width; PCT: platelet crit; ANOVA test.