Research Article
Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma
Table 3
Comparison of risk factors associated with reduced glomerular filtration rate estimated by CKD-EPI-creatinine and cystatin C.
| | CKD-EPI-CysC | value | CKD-EPI-sCr | value |
| | eGFR <60 | eGFR >60 | | eGFR <60 | eGFR >60 | | Number of patients (%) | 35 (57) | 26 (43) | | 21 (34) | 40 (66) | | Number of women (%) | 14 (40) | 10 (38) | 0.924 | 6 (28.6) | 18 (45) | 0.819 | Mean age (years ± SD) | 71 ± 11 | 64 ± 10 | 0.013 | 72 ± 12 | 66 ± 9 | 0.0317 | β-2-Microglobulin >3.5 mg/L | 29 (83) | 9 (35) | 0.018 | 20 (95) | 18 (45) | 0.023 | 8.9 ± 6.3 | 3.38 ± 1.47 | 0.0001 | 10.9 ± 6.9 | 4.2 ± 2.2 | <0.0001 | Hemoglobin <10 g/dL | 14 (40) | 4 (15) | 0.740 | 9 (43) | 9 (22) | 0.769 | 10.4 ± 1.9 | 12.6 ± 2.7 | 0.0004 | 10.5 ± 1.97 | 11.8 ± 2.6 | 0.0495 | Serum urate (mg/dL) | 7.1 ± 2.7 | 5.7 ± 1.81 | 0.025 | 8.4 ± 2.5 | 5.5 ± 1.7 | <0.0001 | Mean urine monoclonal component (g/L) (95% CI) | 0.2 (0.07–0.54) | 0.015 (0–0.12) | 0.003 | 0.32 (0.07–0.84) | 0.03 (0–0.12) | 0.0021 | Mean 24 h-urine proteinuria (g/L) (95% CI) | 0.53 (0.25–1.29) | 0.21 (0.09–0.31) | 0.004 | 1.24 (0.29–1.84) | 0.23 (0.11–0.39) | 0.0002 | Albumin <35 g/L | 21 (60) | 5 (14) | 0.176 | 9 (43) | 19 (47.5) | 0.854 | 34.1 ± 6.8 | 38.05 ± 4.77 | 0.0137 | 34.8 ± 6.5 | 36.6 ± 6 | 0.31 | R-ISS-3 | 13 (37.1) | 1 (3.8) | 0.002 | 10 (47.6) | 4 (10) | 0.003 |
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